Treatment of antiphospholipid antibody syndrome

نویسندگان

  • Ali A Mehdi
  • Imad Uthman
  • Munther Khamashta
  • Elisa Manzotti
چکیده

Antiphospholipid antibody syndrome (APS) is a systemic autoimmune disease with thrombotic predilection resulting in vascular thrombotic events and obstetric complications. Management of APS focuses on anticoagulation; however, despite the solid evidence suggesting that this is the best treatment option available, a lot of debate persists regarding the intensity and duration of anticoagulation needed in the various subsets of APS. Thus, there are currently no uniformly agreed upon management algorithm for APS. This article reviews the clinical and serological criteria defining this syndrome and presents the latest evidence with regard to the optimal management of the various aspects of APS. Here we present our evidence-based recommendations for proper APS management. We conclude by shedding light on possible therapeutic options that may be available in the near future.

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تاریخ انتشار 2010